Remote control of neuronal activity
The ability to control cellular excitability remotely has many implications for basic science and clinical treatments. One form of energy, sonic waves of high frequency (ultrasound), is particularly well suited for this purpose as it can be focused into confined targets deep in biological tissues. We investigate the biophysical interactions of ultrasound with tissues. We assess the efficacy and safety of the interactions in animal and human models.
Remotely-controlled drug release at a specific target
The ability to deliver a drug selectively at a specific location within the body would revolutionize medicine. Building on the pioneering approach of Natalya Rapoport (University of Utah), we use ultrasound to release drugs from specifically designed nanoparticle carriers. We optimize the efficacy and safety of the approach in large animals.